The Preuss Foundation Seminar on
"State of the Art Parkinson’s Disease Research"
La Jolla, California
February 27 - March 1, 2019
Participants
Charles H. Adler, M.D., Ph.D.
Mayo Clinic College of Medicine
Scottsdale, AZ
Cecilia Lindestam Arlehamn, Ph.D.
La Jolla Institute for Allergy and Immunology
La Jolla, CA
​
Daniela Berg, M.D.
Christians-Albrechts University
Kiel, Germany
​
Anders Björklund, M.D., Ph.D.
Lund University
Lund, Sweden
​
Alexis Brice, M.D.
Hôpital de la Pitié-Salpêtrière
Paris, France
​
Patrik Brundin, M.D., Ph.D.
Van Andel Institute
Grand Rapids, MI
​
Don W. Cleveland, Ph.D.
University of California, San Diego
La Jolla, CA
​
Ana Maria Cuervo, M.D., Ph.D.
Albert Einstein College of Medicine
Bronx, NY
​
Valina L. Dawson, Ph.D.
Institute for Cell Engineering
Baltimore, MD
​
Dennis W. Dickson, M.D.
Mayo Clinic
Jacksonville, FL
​
Robert Edwards, M.D.
University of California, San Francisco
San Francisco, CA
​
Alberto J. Espay, M.D., MSc, FAAN
James J. and Joan A. Gardner Family Center for Parkinson’s Disease and Movement Disorders
Cincinnati, OH
​
Mark Frasier, Ph.D.
Michael J. Fox Foundation for Parkinson’s Research
New York, NY
​
Fred H. Gage, Ph.D. - Co-chairperson
The Salk Institute for Biological Studies
La Jolla, CA
Douglas R. Galasko, M.D.
University of California, San Diego
La Jolla, CA
​
J. Timothy Greenamyre, M.D., Ph.D.
Pittsburgh Institute for Neurodegenerative Diseases
Pittsburgh, PA
​
John Hardy, Ph.D. FMedSci, FRS
University College London
London, England
​
Matthew C. Havrda, Ph.D.
Dartmouth-Hitchcock Medical Center
Lebanon, NH
​
Mark A. Israel, M.D.
Israel Cancer Research Fund
New York, NY
​
Stuart W. Jamieson, MB, FRCS, FACS, FACC, FACCP
UC San Diego Health
La Jolla, CA
​
Jeffrey Kordower, Ph.D.
Rush University Medical Center
Chicago, IL
​
Anthony Lang, O.C., M.D., FRCPC, FAAN, FCAHS, FRSC
Toronto Western Hospital
Toronto, Canada
​
Virginia Man-Yee Lee, Ph.D.
University of Pennsylvania, Perelman School of Medicine
Philadelphia, PA
​
Irene Litvan, M.D. - Co-chairperson
University of California, San Diego
La Jolla, CA
​
Katherine Longardner, M.D.
University of California, San Diego
La Jolla, CA
​
Jeanne F. Loring, Ph.D.
The Scripps Research Institute
San Diego, CA
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Lorraine A. Marin, M.D., M.B.A.
Healthcare Partners, IPA, MSO
Garden City, NY
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Eliezer Masliah, M.D.
National Institute on Aging
Bethesda, MD
Sarkis K. Mazmanian, Ph.D.
California Institute of Technology
Pasadena, CA
​
José A. Obeso, M.D.
A.C.HM CINAC Integral Neurosciences Centre
Madrid, Spain
​
Haydeh Payami, Ph.D.
University of Alabama at Birmingham
Birmingham, AL
​
Peter Preuss
The Preuss Foundation, Inc.
La Jolla, CA
​
Serge Przedborski, M.D., Ph.D.
Columbia University
New York, NY
​
Alessandro Sette, Ph.D.
La Jolla Institute for Allergy and Immunology
La Jolla, CA
​
Andrew B. Singleton, Ph.D.
NIA IRP NIH
Bethesda, MD
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David G. Standaert, M.D., Ph.D.
The University of Alabama at Birmingham
Birmingham, AL
​
Diane Stephenson, Ph.D.
Critical Path Institute
Tucson, AZ
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David Sulzer, Ph.D.
Columbia University
New York, NY
​
D. James Surmeier, Ph.D.
Northwestern University
Chicago, IL
​
Caroline M. Tanner, M.D., Ph.D., FAAN
University of California, San Francisco
San Francisco, CA
​
John Q. Trojanowski, M.D, Ph.D.
University of Pennsylvania School of Medicine
Philadelphia, PA
​
David E. Vaillancourt, Ph.D.
University of Florida, Gainesville
Gainesville, FL
​
Agenda
Wednesday, February 27, 2019:
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6:15 pm Ground transfer to Preuss’ La Jolla residence
6:30 pm Opening Session/Reception
8:30 pm Return to hotel
​
​
Thursday, February 28, 2019:
6:00 am Buffet Breakfast
Location: Estancia Hotel ~ Grande Room
7:30 am Transfer to The Salk Institute for Biological Studies
8:00 am Opening Remarks
Location: Trustee Room at The Salk Institute
8:00 - 8:05 Peter Preuss ~ Introduction to The Preuss Foundation
8:05 - 8:15 Co-Chairs: Irene Litvan and Fred H. Gage ~ Opening Comments
​
8:15 am Session I: Rethinking PD: From a Single Disease to Multiple Diseases: Genetics,
Epigenetics and Environmental Factors
8:15 - 8:25 Anthony Lang~ Diagnosing PD
8:25 - 8:35 Caroline Tanner ~ Environmental Factors
8:35 - 8:45 John Hardy ~ Genetics/Epigenetics
8:45 - 8:55 Serge Przedborski ~ Molecular Mechanisms of Mitochondria
8:55 - 9:15 Alexis Brice ~ Session Chair
9:15 - 10:00 Discussion
10:00 am Break
10:15 am Session II: Etiopathogenesis in PD: Single Disease or Multiple Diseases?
10:15 - 10:25 Ana Maria Cuervo ~ Chaperone-mediated Autophagy and Neuroproteotoxicity
10:25 - 10:35 James Surmeier ~ Calcium and Neuronal Vulnerability
10:35 - 10:45 David Sulzer ~ Animal and Cell models
10:45 - 10:55 Alessandro Sette ~ T cell Profiling Section
10:55 - 11:05 Dennis Dickson ~ Ubiquitin-Proteasome System
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11:05 am Session II (continued)
11:05 - 11:15 John Trojanowski ~ Co-pathologies for PD and Synucleinopathies
11:15 - 11:30 Andrew Singleton ~ Genetic Mutations
11:30 - 11:45 Valina Dawson ~ Session Chair
11:45 - 12:30 Discussion
12:30 pm Luncheon
1:30 pm Session III: Spreading of pathology in Single vs. Multiple Diseases
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1:30 - 1:40 Jeffrey Kordower ~ Features and Mechanisms of Spreading
1:40 - 1:50 José Obeso ~ Does Spreading Explain "The Real" Parkinson's Disease
1:50 - 2:00 Virginia Lee ~ Spreading in other Neurodegenerative Diseases
2:00 - 2:10 Alberto Espay ~ Role of a-Synuclein, is it a Bystander?
2:10 - 2:20 Haydeh Payami ~ Role of Microbiome: An Opportunity for Uncovering PD Subtypes?
2:20 - 2:30 Patrik Brundin ~ Session Chair
2:30 - 3:15 Discussion
3:15 pm Break
3:30 pm Session IV Therapeutic Approaches: Disease modifying in Single or Multiple Parkinson Diseases
3:30 - 3:40 Anders Björklund ~ Transplantation Approaches
3:40 - 3:50 Timothy Greenamyre ~ LRRK2 and Idiopathic Parkinson’s Disease
3:50 - 4:00 Eliezer Masliah ~ Immunotherapy Approach
4:00 - 4:10 Don W. Cleveland ~ ASOs - What and Whom to Target?
4:10 - 4:20 David Standaert ~ Session Chair
4:20 - 5:00 Discussion
05:00 pm Adjourn
7:00 pm Reception and dinner
9:30 pm Location: Estancia Hotel~ Adobe Room
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Friday, March 1, 2019:
06:00 am Buffet Breakfast
Location: Estancia Hotel ~ Grande Room
7:30 am Transfer to The Salk Institute for Biological Studies
8:00 am Session V: BioMarkers for PD ~ From Predicting “Prodromic PD
Conversion to “What Type of” PD?
Location: Trustee Room at The Salk Institute
8:00 - 8:10 Mark Frasier ~ Search for BioMarkers
8:10 - 8:20 Daniela Berg ~ Are Clinical Measures Sensitive to Different Subtype Conversion?
8:20 - 8:30 David Vaillancourt ~ Imaging: Is there a Role in Patient Selection and Response Monitoring
8:30 - 8:40 Douglas Galasko ~ CSF: Is there a Role in Patient Selection and Response Monitoring?
8:40 - 8:50 Charles Adler ~ Is there a Role of Peripheral Tissue Biomarkers in Patient Selection and Response Monitoring?
8:50 - 9:00 Sarkis Mazmanian ~ Monitoring the Microbiota
9:00 - 9:10 José Obeso ~ Session Chair
9:10 - 10:00 Discussion
10:00 am Break
10:15 am Summary by Each Session Chair
11:30 am Adjourn