CONTACT

© 2019 The Preuss Foundation, Inc.

2223 Avenida de la Playa, Ste. 220

La Jolla, CA 92037

Tel 858-454-0200

The Preuss Foundation Seminar on

"State of the Art Parkinson’s Disease Research"

La Jolla, California
February 27 - March 1, 2019

Participants

Charles H. Adler, M.D., Ph.D.
Mayo Clinic College of Medicine

Scottsdale, AZ

Cecilia Lindestam Arlehamn, Ph.D.

La Jolla Institute for Allergy and Immunology

La Jolla, CA

Daniela Berg, M.D.

Christians-Albrechts University

Kiel, Germany

Anders Björklund, M.D., Ph.D.

Lund University

Lund, Sweden

Alexis Brice, M.D.

Hôpital de la Pitié-Salpêtrière

Paris, France

Patrik Brundin, M.D., Ph.D.

Van Andel Institute

Grand Rapids, MI

Don W. Cleveland, Ph.D.

University of California, San Diego

La Jolla, CA

Ana Maria Cuervo, M.D., Ph.D.

Albert Einstein College of Medicine

Bronx, NY

Valina L. Dawson, Ph.D.

Institute for Cell Engineering

Baltimore, MD

Dennis W. Dickson, M.D.

Mayo Clinic

Jacksonville, FL

Robert Edwards, M.D.

University of California, San Francisco

San Francisco, CA

Alberto J. Espay, M.D., MSc, FAAN

James J. and Joan A. Gardner Family Center for Parkinson’s Disease and Movement Disorders

Cincinnati, OH

Mark Frasier, Ph.D.

Michael J. Fox Foundation for Parkinson’s Research

New York, NY

Fred H. Gage, Ph.D. - Co-chairperson

The Salk Institute for Biological Studies

La Jolla, CA

Douglas R. Galasko, M.D.

University of California, San Diego

La Jolla, CA

J. Timothy Greenamyre, M.D., Ph.D.

Pittsburgh Institute for Neurodegenerative Diseases

Pittsburgh, PA

John Hardy, Ph.D. FMedSci, FRS

University College London

London, England

Matthew C. Havrda, Ph.D.

Dartmouth-Hitchcock Medical Center

Lebanon, NH

Mark A. Israel, M.D.

Israel Cancer Research Fund

New York, NY

Stuart W. Jamieson, MB, FRCS, FACS, FACC, FACCP

UC San Diego Health

La Jolla, CA

Jeffrey Kordower, Ph.D.

Rush University Medical Center

Chicago, IL

Anthony Lang, O.C., M.D., FRCPC, FAAN, FCAHS, FRSC

Toronto Western Hospital

Toronto, Canada

Virginia Man-Yee Lee, Ph.D.

University of Pennsylvania, Perelman School of Medicine

Philadelphia, PA

Irene Litvan, M.D. - Co-chairperson

University of California, San Diego

La Jolla, CA

Katherine Longardner, M.D.

University of California, San Diego

La Jolla, CA

Jeanne F. Loring, Ph.D.

The Scripps Research Institute

San Diego, CA

Lorraine A. Marin, M.D., M.B.A.

Healthcare Partners, IPA, MSO

Garden City, NY

Eliezer Masliah, M.D.

National Institute on Aging

Bethesda, MD

Sarkis K. Mazmanian, Ph.D.

California Institute of Technology

Pasadena, CA

José A. Obeso, M.D.

A.C.HM CINAC Integral Neurosciences Centre

Madrid, Spain

Haydeh Payami, Ph.D.

University of Alabama at Birmingham

Birmingham, AL

Peter Preuss

The Preuss Foundation, Inc.

La Jolla, CA

Serge Przedborski, M.D., Ph.D.

Columbia University

New York, NY

Alessandro Sette, Ph.D.

La Jolla Institute for Allergy and Immunology

La Jolla, CA

Andrew B. Singleton, Ph.D.

NIA IRP NIH

Bethesda, MD

David G. Standaert, M.D., Ph.D.

The University of Alabama at Birmingham

Birmingham, AL

Diane Stephenson, Ph.D.

Critical Path Institute

Tucson, AZ

David Sulzer, Ph.D.

Columbia University

New York, NY

D. James Surmeier, Ph.D.

Northwestern University

Chicago, IL

Caroline M. Tanner, M.D., Ph.D., FAAN

University of California, San Francisco

San Francisco, CA

John Q. Trojanowski, M.D, Ph.D.

University of Pennsylvania School of Medicine

Philadelphia, PA

David E. Vaillancourt, Ph.D.

University of Florida, Gainesville

Gainesville, FL

Agenda

Wednesday, February 27, 2019:

6:15 pm                Ground transfer to Preuss’ La Jolla residence

6:30 pm                Opening Session/Reception

8:30 pm                Return to hotel

Thursday, February 28, 2019:

 

6:00 am                Buffet Breakfast

                            Location: Estancia Hotel ~ Grande Room

 

7:30 am                Transfer to The Salk Institute for Biological Studies

 

8:00 am               Opening Remarks

                            Location: Trustee Room at The Salk Institute

                                   

8:00 - 8:05           Peter Preuss ~ Introduction to The Preuss Foundation

8:05 - 8:15           Co-Chairs: Irene Litvan and Fred H. Gage ~ Opening Comments

8:15 am                Session I: Rethinking PD: From a Single Disease to Multiple Diseases: Genetics,

                            Epigenetics and Environmental Factors

 

8:15 - 8:25            Anthony Lang~ Diagnosing PD

8:25 - 8:35            Caroline Tanner ~ Environmental Factors

8:35 - 8:45            John Hardy ~ Genetics/Epigenetics

8:45 - 8:55            Serge Przedborski ~ Molecular Mechanisms of Mitochondria

8:55 - 9:15            Alexis Brice ~ Session Chair

9:15 - 10:00          Discussion

 

10:00 am               Break

 

10:15 am             Session II: Etiopathogenesis in PD: Single Disease or Multiple Diseases?

 

10:15 - 10:25       Ana Maria Cuervo ~ Chaperone-mediated Autophagy and Neuroproteotoxicity

10:25 - 10:35       James Surmeier ~ Calcium and Neuronal Vulnerability

10:35 - 10:45       David Sulzer ~ Animal and Cell models

10:45 - 10:55       Alessandro Sette ~ T cell Profiling Section 

10:55 - 11:05       Dennis Dickson ~ Ubiquitin-Proteasome System

11:05 am            Session II (continued)

 

11:05 - 11:15       John Trojanowski ~ Co-pathologies for PD and Synucleinopathies

11:15 - 11:30       Andrew Singleton ~ Genetic Mutations

11:30 - 11:45       Valina Dawson ~ Session Chair

11:45 - 12:30       Discussion

 

12:30 pm             Luncheon

 

1:30 pm               Session III: Spreading of pathology in Single vs. Multiple Diseases

1:30 - 1:40            Jeffrey Kordower ~ Features and Mechanisms of Spreading

1:40 - 1:50            José Obeso ~ Does Spreading Explain "The Real" Parkinson's Disease

1:50 - 2:00            Virginia Lee ~ Spreading in other Neurodegenerative Diseases

2:00 - 2:10            Alberto Espay ~ Role of a-Synuclein, is it a Bystander?

2:10 - 2:20            Haydeh Payami ~ Role of Microbiome: An Opportunity for Uncovering PD Subtypes? 

2:20 - 2:30            Patrik Brundin ~ Session Chair

2:30 - 3:15            Discussion          

 

3:15 pm                Break

 

3:30 pm               Session IV Therapeutic Approaches: Disease modifying in Single or Multiple Parkinson Diseases

 

3:30 - 3:40             Anders Björklund ~ Transplantation Approaches

3:40 - 3:50             Timothy Greenamyre ~ LRRK2 and Idiopathic Parkinson’s Disease

3:50 - 4:00             Eliezer Masliah ~ Immunotherapy Approach

4:00 - 4:10             Don W. Cleveland ~ ASOs - What and Whom to Target?

4:10 - 4:20             David Standaert ~ Session Chair

4:20 - 5:00             Discussion

 

05:00 pm            Adjourn

 

7:00 pm                Reception and dinner

9:30 pm                Location: Estancia Hotel~ Adobe Room

Friday, March 1, 2019:

 

06:00 am             Buffet Breakfast

                           Location: Estancia Hotel ~ Grande Room

 

7:30 am                Transfer to The Salk Institute for Biological Studies

                 

8:00 am                Session V: BioMarkers for PD ~ From Predicting “Prodromic PD

                            Conversion to “What Type of” PD?

                            Location: Trustee Room at The Salk Institute

 

8:00 - 8:10           Mark Frasier ~ Search for BioMarkers

8:10 - 8:20           Daniela Berg ~ Are Clinical Measures Sensitive to Different Subtype Conversion?

8:20 - 8:30           David Vaillancourt ~ Imaging: Is there a Role in Patient Selection and Response Monitoring

8:30 - 8:40           Douglas Galasko ~ CSF: Is there a Role in Patient Selection and Response Monitoring?

8:40 - 8:50           Charles Adler ~ Is there a Role of Peripheral Tissue Biomarkers in Patient Selection and Response Monitoring?

8:50 - 9:00           Sarkis Mazmanian ~ Monitoring the Microbiota

9:00 - 9:10            José Obeso ~ Session Chair

9:10 - 10:00         Discussion

 

10:00 am              Break

 

10:15 am              Summary by Each Session Chair

 

11:30 am              Adjourn