The Preuss Foundation Seminar on
"State of the Art Parkinson’s Disease Research"
La Jolla, California
February 27 - March 1, 2019
Participants
Charles H. Adler, M.D., Ph.D.
Mayo Clinic College of Medicine
Scottsdale, AZ
Cecilia Lindestam Arlehamn, Ph.D.
La Jolla Institute for Allergy and Immunology
La Jolla, CA
Daniela Berg, M.D.
Christians-Albrechts University
Kiel, Germany
Anders Björklund, M.D., Ph.D.
Lund University
Lund, Sweden
Alexis Brice, M.D.
Hôpital de la Pitié-Salpêtrière
Paris, France
Patrik Brundin, M.D., Ph.D.
Van Andel Institute
Grand Rapids, MI
Don W. Cleveland, Ph.D.
University of California, San Diego
La Jolla, CA
Ana Maria Cuervo, M.D., Ph.D.
Albert Einstein College of Medicine
Bronx, NY
Valina L. Dawson, Ph.D.
Institute for Cell Engineering
Baltimore, MD
Dennis W. Dickson, M.D.
Mayo Clinic
Jacksonville, FL
Robert Edwards, M.D.
University of California, San Francisco
San Francisco, CA
Alberto J. Espay, M.D., MSc, FAAN
James J. and Joan A. Gardner Family Center for Parkinson’s Disease and Movement Disorders
Cincinnati, OH
Mark Frasier, Ph.D.
Michael J. Fox Foundation for Parkinson’s Research
New York, NY
Fred H. Gage, Ph.D. - Co-chairperson
The Salk Institute for Biological Studies
La Jolla, CA
Douglas R. Galasko, M.D.
University of California, San Diego
La Jolla, CA
J. Timothy Greenamyre, M.D., Ph.D.
Pittsburgh Institute for Neurodegenerative Diseases
Pittsburgh, PA
John Hardy, Ph.D. FMedSci, FRS
University College London
London, England
Matthew C. Havrda, Ph.D.
Dartmouth-Hitchcock Medical Center
Lebanon, NH
Mark A. Israel, M.D.
Israel Cancer Research Fund
New York, NY
Stuart W. Jamieson, MB, FRCS, FACS, FACC, FACCP
UC San Diego Health
La Jolla, CA
Jeffrey Kordower, Ph.D.
Rush University Medical Center
Chicago, IL
Anthony Lang, O.C., M.D., FRCPC, FAAN, FCAHS, FRSC
Toronto Western Hospital
Toronto, Canada
Virginia Man-Yee Lee, Ph.D.
University of Pennsylvania, Perelman School of Medicine
Philadelphia, PA
Irene Litvan, M.D. - Co-chairperson
University of California, San Diego
La Jolla, CA
Katherine Longardner, M.D.
University of California, San Diego
La Jolla, CA
Jeanne F. Loring, Ph.D.
The Scripps Research Institute
San Diego, CA
Lorraine A. Marin, M.D., M.B.A.
Healthcare Partners, IPA, MSO
Garden City, NY
Eliezer Masliah, M.D.
National Institute on Aging
Bethesda, MD
Sarkis K. Mazmanian, Ph.D.
California Institute of Technology
Pasadena, CA
José A. Obeso, M.D.
A.C.HM CINAC Integral Neurosciences Centre
Madrid, Spain
Haydeh Payami, Ph.D.
University of Alabama at Birmingham
Birmingham, AL
Peter Preuss
The Preuss Foundation, Inc.
La Jolla, CA
Serge Przedborski, M.D., Ph.D.
Columbia University
New York, NY
Alessandro Sette, Ph.D.
La Jolla Institute for Allergy and Immunology
La Jolla, CA
Andrew B. Singleton, Ph.D.
NIA IRP NIH
Bethesda, MD
David G. Standaert, M.D., Ph.D.
The University of Alabama at Birmingham
Birmingham, AL
Diane Stephenson, Ph.D.
Critical Path Institute
Tucson, AZ
David Sulzer, Ph.D.
Columbia University
New York, NY
D. James Surmeier, Ph.D.
Northwestern University
Chicago, IL
Caroline M. Tanner, M.D., Ph.D., FAAN
University of California, San Francisco
San Francisco, CA
John Q. Trojanowski, M.D, Ph.D.
University of Pennsylvania School of Medicine
Philadelphia, PA
David E. Vaillancourt, Ph.D.
University of Florida, Gainesville
Gainesville, FL
Agenda
Wednesday, February 27, 2019:
6:15 pm Ground transfer to Preuss’ La Jolla residence
6:30 pm Opening Session/Reception
8:30 pm Return to hotel
Thursday, February 28, 2019:
6:00 am Buffet Breakfast
Location: Estancia Hotel ~ Grande Room
7:30 am Transfer to The Salk Institute for Biological Studies
8:00 am Opening Remarks
Location: Trustee Room at The Salk Institute
8:00 - 8:05 Peter Preuss ~ Introduction to The Preuss Foundation
8:05 - 8:15 Co-Chairs: Irene Litvan and Fred H. Gage ~ Opening Comments
8:15 am Session I: Rethinking PD: From a Single Disease to Multiple Diseases: Genetics,
Epigenetics and Environmental Factors
8:15 - 8:25 Anthony Lang~ Diagnosing PD
8:25 - 8:35 Caroline Tanner ~ Environmental Factors
8:35 - 8:45 John Hardy ~ Genetics/Epigenetics
8:45 - 8:55 Serge Przedborski ~ Molecular Mechanisms of Mitochondria
8:55 - 9:15 Alexis Brice ~ Session Chair
9:15 - 10:00 Discussion
10:00 am Break
10:15 am Session II: Etiopathogenesis in PD: Single Disease or Multiple Diseases?
10:15 - 10:25 Ana Maria Cuervo ~ Chaperone-mediated Autophagy and Neuroproteotoxicity
10:25 - 10:35 James Surmeier ~ Calcium and Neuronal Vulnerability
10:35 - 10:45 David Sulzer ~ Animal and Cell models
10:45 - 10:55 Alessandro Sette ~ T cell Profiling Section
10:55 - 11:05 Dennis Dickson ~ Ubiquitin-Proteasome System
11:05 am Session II (continued)
11:05 - 11:15 John Trojanowski ~ Co-pathologies for PD and Synucleinopathies
11:15 - 11:30 Andrew Singleton ~ Genetic Mutations
11:30 - 11:45 Valina Dawson ~ Session Chair
11:45 - 12:30 Discussion
12:30 pm Luncheon
1:30 pm Session III: Spreading of pathology in Single vs. Multiple Diseases
1:30 - 1:40 Jeffrey Kordower ~ Features and Mechanisms of Spreading
1:40 - 1:50 José Obeso ~ Does Spreading Explain "The Real" Parkinson's Disease
1:50 - 2:00 Virginia Lee ~ Spreading in other Neurodegenerative Diseases
2:00 - 2:10 Alberto Espay ~ Role of a-Synuclein, is it a Bystander?
2:10 - 2:20 Haydeh Payami ~ Role of Microbiome: An Opportunity for Uncovering PD Subtypes?
2:20 - 2:30 Patrik Brundin ~ Session Chair
2:30 - 3:15 Discussion
3:15 pm Break
3:30 pm Session IV Therapeutic Approaches: Disease modifying in Single or Multiple Parkinson Diseases
3:30 - 3:40 Anders Björklund ~ Transplantation Approaches
3:40 - 3:50 Timothy Greenamyre ~ LRRK2 and Idiopathic Parkinson’s Disease
3:50 - 4:00 Eliezer Masliah ~ Immunotherapy Approach
4:00 - 4:10 Don W. Cleveland ~ ASOs - What and Whom to Target?
4:10 - 4:20 David Standaert ~ Session Chair
4:20 - 5:00 Discussion
05:00 pm Adjourn
7:00 pm Reception and dinner
9:30 pm Location: Estancia Hotel~ Adobe Room
Friday, March 1, 2019:
06:00 am Buffet Breakfast
Location: Estancia Hotel ~ Grande Room
7:30 am Transfer to The Salk Institute for Biological Studies
8:00 am Session V: BioMarkers for PD ~ From Predicting “Prodromic PD
Conversion to “What Type of” PD?
Location: Trustee Room at The Salk Institute
8:00 - 8:10 Mark Frasier ~ Search for BioMarkers
8:10 - 8:20 Daniela Berg ~ Are Clinical Measures Sensitive to Different Subtype Conversion?
8:20 - 8:30 David Vaillancourt ~ Imaging: Is there a Role in Patient Selection and Response Monitoring
8:30 - 8:40 Douglas Galasko ~ CSF: Is there a Role in Patient Selection and Response Monitoring?
8:40 - 8:50 Charles Adler ~ Is there a Role of Peripheral Tissue Biomarkers in Patient Selection and Response Monitoring?
8:50 - 9:00 Sarkis Mazmanian ~ Monitoring the Microbiota
9:00 - 9:10 José Obeso ~ Session Chair
9:10 - 10:00 Discussion
10:00 am Break
10:15 am Summary by Each Session Chair
11:30 am Adjourn